Table 2.

Research needs to address artemisinin resistance

1. Discover the mechanisms of artemisinin drug action and parasite resistance to artemisinins.

2. Conduct in vivo parasite clearance rate studies for monitoring and surveillance of the phenotype.

3. Develop new ex vivo and in vitro antimalarial drug response assays.

4. Discover molecular markers for resistance.

5. Create low-cost rapid tests to measure drug quality.

6. Discover treatments that kill artemisinin-resistant parasites and block their transmission to mosquitoes.

7. Discover new partner drugs for combination with artemisinins to treat malaria.

8. Build research models to estimate the impact of artemisinin resistance spreading to other endemic regions, to help plan emergency preparedness strategies.