Table 2.
Group description | Group | Viable cysts in muscle† | Viable cysts in brain | ||||||
---|---|---|---|---|---|---|---|---|---|
Median (range) | P‡ | P§ | Efficacy, % | Median (range) | P‡ | P§ | Efficacy, % | ||
No treatment | 7 | 7,078 (2,072–11,746) | Ref. | Ref. | Reference | 25 (16–53) | Ref. | Ref. | Reference |
PZQ alone | 2 | 6,515 (2,260–7,985) | 0.873 | 0.09 | 8.0 | 46 (6–82) | 0.631 | 0.07 | 0 |
Prednisone | 6 | 5,401 (2,121–10,926) | 1.00 | 0.02 | 23.7 | 38 (26–54) | 0.273 | 0.02 | 0 |
NZX | 5 | 9,433 (7,433–12,731) | 0.423 | 0.01 | 0 | 18 (8–54) | 0.631 | 0.12 | 28 |
OFZ | 4 | 0 (0–0) | 0.003 | 0.90 | 100 | 10 (1–13) | 0.055 | 0.34 | 60 |
ABZ + PDN | 1 | 0 (0–0) | 0.004 | 0.90 | 100 | 0 (0–4) | 0.017 | 0.39 | 100 |
ABZ + PZQ + PDN | 3 | 0 (0–0) | 0.005 | 0.90 | 100 | 0 (0–0) | 0.009 | 0.41 | 100 |
½ ABZ + PZQ + PDN | 8 | 0 (0–0) | 0.002 | 0.90 | 100 | 0 (0–1) | 0.007 | 0.34 | 100 |
ABZ + PZQ + 2 PDN | 9 | 0 (0–0) | 0.002 | 0.90 | 100 | 0 (0–1) | 0.007 | 0.41 | 100 |
Ref. = referent; PZQ = praziquantel; NZX = nitazoxanide; OFZ = oxfendazole; ABZ = albendazole; PDN = prednisone.
Numbers of cysts in muscle are adjusted by weight.
Mann-Whitney test (compared with the reference group).
Power.