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Proteasome-dependent regulation of MHC class I-restricted antigen presentation on hepatocytes by HCV and ethanol (working hypothesis): HCV and ethanol induce oxidative stress and impaired methylation status in hepatocytes. This affects the proteasome composition and consequently inhibits proteasome activity and peptide processing, which ultimately suppress the display of peptide-MHC class I complexes on hepatocytes, the targets for CTLs.
