Table 2.
Results of microarray experiments ; dysregulated synaptic genes in the hippocampal sub-regions of subjects with major depressive disorder
| DG |
CA1 |
|||||
|---|---|---|---|---|---|---|
| Gene name | Symbol | RefSeq ID | Fold change | p value | Fold change | p value |
| Synaptic function | ||||||
| Pre-synaptic | ||||||
| Synapsin 1 | SYN1 | NM_006950.2 | 0.97 | 0.936 | 0.86 | 0.628 |
| Synapsin 3 | SYN3 | NM_133632.1 | 0.93 | 0.673 | 0.57 | 0.0005* |
| Synaptosomal-associated protein, 25 kDa |
SNAP25 | NM_130811.1 | 0.40 | 0.036* | 0.39 | 0.004* |
| Post-synaptic | ||||||
| Synapse-associated protein 97 | DLG10/SAP97 | NM_004087.2 | 0.86 | 0.225 | 0.84 | 0.248 |
| Synapse-associated protein 93 | DLG2/SAP93 | NM_001364 | 0.41 | 0.007* | 0.50 | 0.008* |
| Synapse-associated protein 102 | DLG3/SAP102 | NM_020730.1 | 0.81 | 0.014* | 0.81 | 0.003* |
| Synapse-associated protein 95 | DLG4/PSD95 | NM_001365.1 | 1.05 | 0.773 | 0.86 | 0.570 |
| Microtubule-associated protein 1a | MAP1a | NM_002373.4 | 0.75 | 0.127 | 0.53 | 0.025* |
| Microtubule-associated protein 1b | MAP1b | NM_005909.2 | 0.68 | 0.130 | 0.56 | 0.004* |
| Microtubule-associated protein 2 | MAP2 | NM_002374.2 | 0.83 | 0.003* | 0.80 | 0.011* |
| Microtubule-associated protein τ | MAPT | NM_016841.1 | 0.29 | 0.0002* | 0.61 | 0.005* |
DG, Dentate gyrus.
*
Indicates statistically significant change in fold change where p<0.05.