Table 1.
Animal cohort information.
Cohort | Age (months) | Group | n | Mean proximity to platform location | Sample Type | Analyses Performed |
---|---|---|---|---|---|---|
1* | 12 | Adult | 5 | 48 ± 1.9cm | Hippocampal synaptosomes | Morris water maze testing, transcriptomic analysis, qPCR, immunoblotting |
28 | Aged Intact | 8 | 52 ± 2.4cm | |||
28 | Aged Impaired | 7 | 68 ± 1.6cm | |||
2# | 12 | Adult | 7 | 49 ± 1.1cm | Hippocampal subregions (CA1, CA3, DG) | Morris water maze testing, qPCR, immunoblotting |
26 | Aged Intact | 7 | 48 ±1.4cm | |||
26 | Aged Impaired | 10 | 59 ± 1.4cm | |||
3 | 26 | Aged | 3 | N/A | Perfusion-fixed sagittal brain sections | immunohistochemistry |
Previously described in VanGuilderet al., 2011a
Previously described in VanGuilderet al., 2011c