Table 5.
qPCR analysis of gene expression.
| Aged vs Adult (ratio, t-test p-valuet) | Aged Intact vs Adult (ratio, SNK p-value) | Aged Impaired vs Adult (ratio, SNK p-value) | Aged Impaired vs Aged Intact (ratio, SNK p-value) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Syn | CA1 | CA3 | DG | Syn | CA1 | CA3 | DG | Syn | CA1 | CA3 | DG | Syn | CA1 | CA3 | DG |
| RT1-A1 | 2.10# | 1.56## | 1.45## | - | 1.88* | 1.63* | 1.51** | - | 2.35* | 1.51* | 1.40* | - | - | - | - | - |
| RT1-A2 | 1.51### | - | - | - | 1.46** | 2.03* | - | - | 1.57* | - | - | - | - | - | - | - |
| RT1-A3 | 1.92## | 1.45### | - | - | - | 1.43** | - | - | 2.22** | 1.47** | - | - | - | - | - | - |
| B2m | 1.49## | - | - | - | 1.48* | - | - | - | 1.50* | - | - | - | - | - | - | - |
| Tap1 | - | - | - | - | - | - | - | - | 1.48* | - | - | - | 1.49* | - | - | - |
| Tap2 | 1.59# | 1.31## | - | - | - | 1.35* | - | - | - | 1.28* | - | - | - | - | - | - |
| Tapbp | 1.32# | - | - | - | - | - | - | - | 1.47* | - | - | - | 1.27* | - | - | - |
| PirB | 1.90# | 1.79### | 1.55## | - | - | 1.89** | 1.60* | - | 2.50*** | 1.72** | 1.49* | - | 1.81** | - | - | - |
| Klra2 | 2.30# | - | 1.91### | - | 2.43* | - | 1.93* | - | 2.16* | - | 1.90** | - | - | - | - | - |
Age-based comparisons: two-tailed t-test with BHMTC (#p<0.05; ##p<0.01; ###p<0.001); three-group data: one-way ANOVA/BHMTC with SNK post hoc (*p<0.05; **p<0.01; ***p<0.001). Data are presented as ratios of group means for the comparisons described in column headings (formatted as numerator vs denominator). Values >1.0 indicate higher transcript levels in the groups used as numerators in the ratio comparisons.