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. Author manuscript; available in PMC: 2013 Apr 24.
Published in final edited form as: Biochemistry. 2012 Apr 10;51(16):3451–3459. doi: 10.1021/bi300070z

Figure 1. Forms of B-domainless FVIII Secreted from BHK cells.

Figure 1

Secreted B-domainless FVIII single chain (A) and heterodimer forms (B). Thrombin cleavage sites indicated by arrows and (☆) represents a furin cleavage site. The B-domain in B-domainless FVIII represents a 14 amino acid remnant connecting the a2 and a3 acidic regions.