Figure 6. A steric double-latch regulates Mt-PatA.
Release of the steric double-latch stabilized by cAMP binding. The N-terminal regulatory domain and the catalytic PAT domain are shown in yellow and magenta, respectively. The lid is shown in cyan, and the C-terminal helix is shown in blue. Cooperative interdomain communication is achieved indirectly, because the changes the regulatory domain stabilized by cAMP are incompatible with the closed lid.
