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Drinking (drinks/day) under natural conditions in non-treatment seeking alcoholics while taking naltrexone and placebo by OPRM1 and DAT genotypes. There was a significant three-way interaction of medication group by OPRM1 by DAT (see text for detail). Those with at least one DAT 9 VNTR and who were OPRM1 asn40 homozygotes had the greatest response to naltrexone. Sample size (n) for each group is given in insert boxes within each column.
