Table 2.
Alcohol consumption during the 5-day natural observation period and after the priming drink in the bar-lab based on OPRM1 genotype and medication group. Asp40 indicates either heterozygous (asn40asp) or homozygous (asp40asp) at the OPRM1 118 locus.
| Naltrexone | Placebo | F (df 1,79) | P | |||
|---|---|---|---|---|---|---|
| asn40asn | asp40 | asn40asn | asp40 | |||
| N | 19 | 19 | 21 | 24 | ||
| 5 Day Drinking: | ||||||
| Drinks/Day | 4.7 ± 1.8 | 5.7 ± 3.2 | 6.2 ± 3.4 | 6.3 ± 3.7 | 0.44 | 0.51 |
| Heavy Drinking Days (%) |
44 ± 21 | 53 ± 27 | 53 ± 24 | 52 ± 27 | 0.85 | 0.36 |
| Bar Lab Drinks | 3.0 ± 2.9 | 3.8 ± 3.1 | 3.8 ± 2.8 | 3.1 ± 3.3 | 1.20 | 0.28 |