Table 1.
Factor | NR2E3 | MAPK9 | CTDSP1 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case N=300 | Control N=300 | Case | Control | Case | Control | Case | Control | |||||||
n (%) | n ( %) | 50% | 75% | 50% | 75% | 50% | 75% | 50% | 75% | 50% | 75% | 50% | 75% | |
Sex | ||||||||||||||
Men | 163 (54) | 162 (54) | 0.79 | 0.99 | 0.75 | 0.84 | 0.80 | 0.90 | 0.77 | 0.85 | 1.09 | 1.30 | 1.03 | 1.26 |
Women | 137 (46) | 138 (46) | 0.84 | 1.10 | 0.76 | 0.86 | 0.81 | 0.93 | 0.74 | 0.85 | 1.06 | 1.28 | 1.01 | 1.18 |
P-value * | 0.75 | 1.0 | 0.26 | |||||||||||
Education (years) | ||||||||||||||
<12 | 37 (12) | 22 (7) | 0.79 | 1.00 | 0.76 | 0.88 | 0.78 | 0.86 | 0.83 | 0.88 | 1.05 | 1.18 | 1.03 | 1.22 |
12 | 91 (30) | 65 (22) | 0.80 | 1.09 | 0.75 | 0.85 | 0.81 | 0.93 | 0.74 | 0.82 | 1.03 | 1.26 | 0.94 | 1.16 |
>12 -<16 | 76 (26) | 82 (27) | 0.77 | 1.04 | 0.76 | 0.86 | 0.77 | 0.88 | 0.75 | 0.88 | 1.06 | 1.24 | 1.02 | 1.20 |
16+ | 96 (32) | 131 (44) | 0.86 | 1.10 | 0.75 | 0.84 | 0.82 | 0.91 | 0.76 | 0.84 | 1.15 | 1.43 | 1.07 | 1.28 |
P-value * | 0.003 | 0.88 | 0.16 | 0.30 | ||||||||||
Tobacco use | ||||||||||||||
never | 85 (28) | 110 (37) | 0.78 | 1.13 | 0.75 | 0.83 | 0.78 | 0.92 | 0.74 | 0.82 | 1.04 | 1.19 | 0.97 | 1.16 |
pipe/cigar | 10 (3) | 10 (3) | 0.85 | 1.00 | 0.77 | 0.80 | 0.78 | 0.88 | 0.79 | 0.87 | 1.22 | 1.38 | 0.99 | 1.16 |
Former | 135 (45) | 143 (48) | 0.83 | 1.00 | 0.77 | 0.87 | 0.81 | 0.91 | 0.78 | 0.86 | 1.10 | 1.37 | 1.06 | 1.30 |
current | 69 (23) | 34 (11) | 0.85 | 1.06 | 0.74 | 0.82 | 0.82 | 0.93 | 0.77 | 0.85 | 1.09 | 1.45 | 0.93 | 1.26 |
P- value * | 0.002 | 0.70 | 0.67 | 0.01 | ||||||||||
Obese | ||||||||||||||
BMI<30 | 269 (90) | 273 (92) | 0.82 | 1.05 | 0.75 | 0.84 | 0.81 | 0.92 | 0.76 | 0.85 | 1.08 | 1.31 | 1.01 | 1.21 |
BMI 30+ | 29 (10) | 25 (8) | 0.87 | 1.12 | 0.80 | 1.20 | 0.79 | 0.93 | 0.80 | 1.00 | 1.06 | 1.20 | 1.15 | 1.47 |
P- value * | 0.57 | 0.04 | 0.10 | 0.21 | ||||||||||
Overweight | ||||||||||||||
BMI<25 | 154 (52) | 177 (59) | 0.82 | 1.02 | 0.75 | 0.84 | 0.81 | 0.91 | 0.74 | 0.84 | 1.07 | 1.30 | 0.98 | 1.18 |
BMI 25+ | 144 (48) | 121 (41) | 0.83 | 1.10 | 0.77 | 0.88 | 0.80 | 0.92 | 0.78 | 0.87 | 1.09 | 1.29 | 1.08 | 1.27 |
P- value * | 0.06 | 0.14 | 0.05 | 0.12 | ||||||||||
Diabetes | ||||||||||||||
No diabetes | 258 (94) | 271 (92) | 0.82 | 1.06 | 0.75 | 0.85 | 0.81 | 0.92 | 0.75 | 0.85 | 1.07 | 1.26 | 1.02 | 1.21 |
Diabetes 5+ yrs | 18 (6) | 22 (8) | 0.86 | 1.13 | 0.78 | 0.84 | 0.82 | 0.93 | 0.82 | 0.87 | 1.13 | 1.40 | 1.07 | 1.31 |
P- value * | 0.65 | 0.22 | 0.78 | 0.29 | ||||||||||
Allergy history | ||||||||||||||
No | 168 (56) | 148 (49) | 0.82 | 1.08 | 0.76 | 0.84 | 0.80 | 0.93 | 0.75 | 0.85 | 1.08 | 1.31 | 1.02 | 1.20 |
Yes | 132 (44) | 152 (51) | 0.83 | 1.05 | 0.75 | 0.86 | 0.81 | 0.90 | 0.77 | 0.85 | 1.09 | 1.27 | 1.03 | 1.26 |
P- value * | 0.10 | 0.63 | 0.46 | 0.40 | ||||||||||
Plants/pollen** | 105 (35) | 113 (38) | 0.82 | 1.04 | 0.75 | 0.84 | 0.80 | 0.92 | 0.74 | 0.85 | 1.11 | 1.32 | 1.02 | 1.22 |
Other allergen** | 25 (8) | 33 (11) | 0.86 | 1.32 | 0.78 | 0.84 | 0.81 | 1.00 | 0.78 | 0.85 | 0.95 | 1.19 | 1.03 | 1.16 |
P- value * | 0.27 | 0.66 | 0.32 | 0.31 | ||||||||||
No. of allergies | ||||||||||||||
0 | 168 (56) | 148 (49) | 0.83 | 1.05 | 0.76 | 0.86 | 0.81 | 0.90 | 0.77 | 0.85 | 1.09 | 1.27 | 1.03 | 1.26 |
1 | 67 (23) | 66 (22) | 0.84 | 1.27 | 0.75 | 0.84 | 0.80 | 1.00 | 0.74 | 0.85 | 1.08 | 1.36 | 1.00 | 1.20 |
2 | 33 (11) | 40 (14) | 0.75 | 0.95 | 0.76 | 0.83 | 0.78 | 0.90 | 0.74 | 0.85 | 1.09 | 1.21 | 1.08 | 1.21 |
3 or more | 30 (10) | 40 (14) | 0.86 | 1.02 | 0.75 | 0.86 | 0.82 | 0.91 | 0.74 | 0.85 | 1.05 | 1.32 | 1.04 | 1.24 |
P- value * | 0.34 | 0.50 | 0.44 | 0.61 |
H0: disease status is independent of the covariate; In controls only, H0: autoantibody level (grouped by 75th percentile) is independent of covariate
Referent is no allergy history
BMI= Body Mass Index (weight in kg/ height in m2); yrs= years; No.= number