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Typical traces showing the effect of intrathecal administration of (a) sarcosine (glycine transporter [GlyT] type 1 inhibitor) and (b) ALX-1393 (GlyT2 inhibitor) on continuous cystometrograms in sham rats. Arrows indicate the timing of drug administration. ALX-1393 showed some inhibitory effects on bladder activity (b), while sarcosine has no apparent effects (a). Vehicle 1: distilled water. Vehicle 2: 100% dimethyl sulfoxide.
IVP = intravesical pressure; i.t. = intrathecal.
