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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Eur Urol. 2012 Feb 1;62(4):704–712. doi: 10.1016/j.eururo.2012.01.044

Fig. 3.

Fig. 3

Typical traces showing the effect of intrathecal administration of (a) sarcosine, (b) ALX-1393, and (c) the combined application of ALX-1393 and strychnine, a glycine receptor antagonist, on continuous cystometrograms in cyclophosphamide (CYP)–treated rats. Arrows indicate the timing of drug administration. ALX-1393 showed inhibitory effects on CYP-induced bladder overactivity (b), while sarcosine has no apparent effects (a). Strychnine antagonized the inhibitory effect of ALX-1393 (c). Vehicle 1: distilled water. Vehicle 2: 100% dimethyl sulfoxide. Vehicle 3: saline).

IVP = intravesical pressure; i.t. = intrathecal.