Effects of intrathecal administration of sarcosine and ALX-1393 on cystometric parameters in (a–d) sham and (e–h) cyclophosphamide (CYP)–treated rats. (a) Each bar represents the mean plus or minus standard error of the mean.
ICI = intercontraction interval; PT = pressure threshold; MVP = maximum voiding pressure; BP = baseline pressure; V = vehicle; SCS = sarcosine (in micrograms, intrathecal); ALX = ALX-1393 (in micrograms, intrathecal); CYP = cyclophosphamide; N/A: not analyzed (ie, the analysis of the parameter was impossible because of the strong suppression of the micturition reflex); ANOVA = analysis of variance.
* p < 0.05.
** p < 0.01 (compared to the vehicle group; one-way ANOVA followed by Bonferroni multiple comparison test); the number of animals (n) in each subgroup was shown in parentheses.