Table 2.
Summary of Clinical Experience with Legalon® SIL in Amatoxin Poisoning
| Reference | Treatment Regimen | No. of Patients | |
|---|---|---|---|
| Treated | Survived | ||
| Lorenz et al., 1983 (unpublished) | PE + SIL | 201 | 181 |
| Strenge-Hesse et al., 1996 (unpublished) | PE + SIL | 154 | 139 |
| Floersheim et al., 1982 [29] | PE + SIL | 16 | 16 |
| Hruby 1983 [30] | PE + SIL | 15 | 14 |
| Marugg and Reutter 1985 [33] | PE + SIL | 12 | 11 |
| Smetana et al., 1986 [34] | PE + SIL | 2 | 2 |
| Schenke et al., 1987 [35] | SIL | 2 | 2 |
| Hruby 1987 [36] | SIL PE + SIL TH + SIL PE + TH + SIL |
17 37 1 15 |
16 34 1 15 |
| Kelbel and Weilemann 1989 [37] | PE + SIL | 5 | 4 |
| Nagy et al., 1994 [38] | PE + SIL | 4 | 3 |
| Kleist-Retzow et al., 1995 [39] | PE + SIL | 2 | 2 |
| Molling et al., 1995 [40] | PE + SIL | 2 | 2 |
| Carducci et al., 1996 [41] | PE + SIL | 4 | 4 |
| Alves et al., 2001 [42] | PE + SIL | 4 | 4 |
| Boyer et al., 2001 [43] | NAC + SIL | 1 | 1 |
| Enjalbert et al., 2002 [28] | SIL or PE+SIL | 624 | 589 |
| Ganzert et al., 2008 [31] | SIL or PE+SIL | 367 | 339 |
| Mitchell and Olson 2008 [32] | PE+NAC+SIL | 6 | 5 |
| Total | 1,491 | 1,384 | |
PE=penicillin, SIL=Legalon® SIL, NAC=N-acetylcysteine, TH=thioctic acid.