Table 1.
Lists of previously reported thyroid T-cell lymphoma
| References* | Age/gender | Presentation | Chronic thyroiditis | HTLV-1 | Histology | Molecular Diagnosis | Diagnostic intervention | Therapy | prognosis |
|---|---|---|---|---|---|---|---|---|---|
| [3] 1977 |
73/F |
|
N/A |
N/A |
|
|
|
S + R |
alive at 24 months |
| [4] 1990 |
79/M |
Goiter |
N/A |
N/A |
Diffuse small cleaved |
|
open biopsy |
C + R |
alive at 4 years |
| [4] 1990 |
80/F |
Goiter |
(+) |
N/A |
Diffuse small cleaved |
|
Hemithyroidectomy |
S |
DUC |
| [5] 1996 |
64/F |
Thyroid mass, Hypothyroidism |
(+) |
(-) |
CD2+, CD3+, CD5+, CD45RO+ |
TCR-β, TCR-γ rearrangement |
Total thyroidectomy |
S + C + R |
alive at 9 months |
| [6] 1997 |
59/F |
Goiter |
(+) |
(-) |
CD3+, CD4-, CD8-, CD19- |
TCR-δ rearrangement |
Open biopsy |
C + R |
alive at 22 months |
| [7] 1999 |
65/M |
Thyroid mass, Horseness, dyspasia, |
(-) |
N/A |
CD45RO+, CD45-, vimentin+ |
|
Open biopsy |
C + R |
died at 11 months |
| [8] 1999 |
39/F |
Goiter, fever, dysphonia |
(+) |
N/A |
CD30+, CD45RO+, CD3-, CD20-, CD79a-, CD21- |
|
Open biopsy |
C + R |
alive at 1 year |
| [9] 2000 |
63/F |
Thyroid mass, Hoarseness, dyspnea |
(+) |
N/A |
CD45RO+, CD43+ |
|
Total thyroidectomy |
S + C + R |
alive at 3 years |
| [10] 2001 |
72/M |
Thyroid mass, pressure, difficulty swallowing |
(+) |
N/A |
CD4+ |
|
Right hemithyroidectomy |
C + R |
alive at 12 months |
| [11] 2005 |
71/F |
Thyroid swelling, horseness, goiter |
(+) |
(-) |
CD3+, CD45RO+, CD4+ |
TCR-β, TCR-γ rearrangement |
Total thyroidectomy |
S |
alive at 25 months |
| [12] 2005 |
86/F |
Swelling of neck |
(-) |
(-) |
CD3e+, CD5+, TIA-1+ (T-cell restricted antigen) |
TCR-Cβ rearrangement |
Left hemithyroidectomy |
S |
alive at 2 years |
| [13] 2007 |
34/M |
N/A |
(-) |
(-) |
CD3+, CD5+, CD7-, CD43+, CD45RO+, CD20- |
|
N/A |
S + C + R |
died at 13 months |
| [14] 2007 |
61/M |
Thyroid mass |
(+) |
(-) |
CD3+, CD4+, |
TCR-β rearrangement |
Open biopsy |
C |
alive at 4 years |
| [14] 2007 |
68/M |
Thyroid mass, dyspnea |
(+) |
(-) |
CD3+, CD4+, TCR-ab+ |
|
Open biopsy |
C |
died at 5 months |
| [15] 2008 |
32/M |
Swelling of neck, fatigue, shortness of breath |
(-) |
N/A |
CD3+, |
TCR-γ rearrangement(PCR) |
Open biopsy |
C |
alive at 1 year |
| present | 70/F | Neck swelling | (+) | (-) | CD3+, CD45RO+, | TCR-β, TCR-γ rearrangement | Total thyroidectomy | S | alive at 20 months |
References*, Number in brackets indicate reference numbers and other numbers indicate published year; N/A, not available; C, chemotherapy; DFS, disease-free survival; DUC, died of unrelated cause; IgH, immunoglobulin heavy chain; PCR, polymerase chain reaction; R, radiation therapy; S, surgery; TCR, T-cell receptor.