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L-NAME-induced upregulation of E-selectin expression in vivo. Immunohistochemical analysis (representative of 4 specimens each) showing E-selectin expression (arrow) in human microvasculature of the human skin xenografts in SCID-hu mice without treatment (control, left panel) and 4 h following L-NAME administration (50 mg/kg b.w., i.p., right panel).
