Table 1.
Thermodynamic parameters for the interaction of Aβ (1–42) with unilamellar vesicles of various lipid compositions
| No. 1 |
No. 2 |
No. 3 |
No. 4 |
No. 5 |
No. 6 |
No. 7 |
No. 8 |
No. 9 |
|
|---|---|---|---|---|---|---|---|---|---|
| SM/Ch/DMPA (48.75:48.75:2.5) | SM/Ch/DMPA (47.5:47.5:5) | SM/Ch/DMPA (45:45:10) | SM/Ch/DMPA (40:40:20) | SM/Ch/CL (47.5:47.5:5) | SM/Ch/CL (40:40:20) | PC | PC/DMPA (95:5) | PC/DMPA (80:20) | |
| Ka (M−1) | 7.8 ± 0.7 × 104 | 3.1 ± 0.9 × 104 | 1.1 ± 0.5 × 104 | 5.8 ± 0.8 × 103 | 1.6 ± 0.2 × 105 | 4.3 ± 0.5 × 104 | 1.4 ± 0.4 × 105 | 4.9 ± 0.36 × 105 | 4.0 ± 0.14 × 105 |
| Kd (μM) | 18.4 ± 0.5 | 32.0 ± 1.1 | 100.0 ± 1.5 | 172.0 ± 12.5 | 6.2 ± 1.2 | 25.0 ± 3.0 | 6.9 ± 1.1 | 2.0 ± 0.1 | 2.5 ± 0.1 |
| ΔH (Kcal/mol) | −2.3 ± 0.2 | −7.3 ± 0.05 | −1.2 ± 0.2 | −2.8 ± 0.19 | −12.6 ± 1.4 | −1.4 ± 0.8 | −2.9 ± 0.1 | −1.5 ± 0.1 | −2.5 ± 0.1 |
| ΔS (cal/mol) | 14.7 ± 0.6 | −3.0 ± 0.1 | 15.0 ± 1.3 | 8.1 ± 0.2 | −16.8 ± 0.4 | 16.4 ± 0.6 | 14.1 ± 0.6 | 21.1 ± 0.5 | 17.6 ± 0.5 |
| ΔG (Kcal/mol) | −6.9 ± 0.3 | −6.4 ± 0.1 | −5.8 ± 0.4 | −5.3 ± 0.01 | −11.9 ± 0.6 | −7.0 ± 0.7 | −7.3 ± 0.3 | −8.0 ± 0.5 | −7.9 ± 0.7 |
Average values mean ± SE (n = 3).