Table 2.

Ion localization inside the cytoplasmic domain: 4 Mg²⁺ + ∼1 M KCl simulations

	Kir1.1/ROMK			Kir2.1/IRK
	Mg2+	K+	Cl−	Mg2+	K+	Cl−
Central pore (R < 15 Å, −9 Å < Z < 15 Å)	2.8 ± 1.0	5.7 ± 0.4	3.1 ± 0.5	2.8 ± 1.2	3.7 ± 1.4	1.9 ± 0.6
PIP2 binding region (5 Å < R < 30 Å, 15 Å < Z < 30 Å)	0.0 ± 0.1	11.3 ± 0.3	30.9 ± 0.8	0.0 ± 0.0	10.8 ± 1.4	27.7 ± 1.1
Constriction region (R < 15 Å, 15 Å < Z < 25 Å)	0.0 ± 0.0	1.7 ± 0.1	1.5 ± 0.2	0.0 ± 0.0	0.8 ± 0.1	1.1 ± 0.2
Cytoplasmic entrance (R < 20 Å, −30 Å < Z < −10Å)	0.2 ± 0.2	10.8 ± 0.7	8.6 ± 0.4	0.2 ± 0.3	20.2 ± 2.9	7.9 ± 0.8
Bulk (R < 40 Å, 35 Å < Z < 40 Å)	0.1 ± 0.0	16.4 ± 0.3	16.7 ± 0.3	0.1 ± 0.0	12.9 ± 2.5	14.0 ± 1.6

All numbers are represented as averages ± SD (n = 3).