Figure 8.

Maximum likelihood majority-rule bootstrap consensus tree of protein disulfide isomerase (PDI) proteins. Green boxes are likely TRX-like fold in human PDI; blue are likely noncatalytic thirodoxin domains (according to Hatahet and Ruddock [62]). White boxes show CxxC catalytic motifs, in C. elegans and D. melanogaster. Although domain structure cannot be inferred from sequence alone, it is likely that proteins that share similar sequences, catalytic motifs, and length also share a similar domain structure and in some cases are likely orthologous. See Figure 5 for details of how the sequences were identified and processed as well as how the phylogenetic analysis was carried out.