Table 3.
Characterised protein disulfide isomerase and their C. elegans orthologs.
| PDI homolog | Known functions |
C. elegans ortholog (paralogs) |
|---|---|---|
| AGR2 | Unknown | None |
|
| ||
| AGR3 | Unknown | None |
|
| ||
| ERp27 | Unknown | (C30H6.8, C35B1.5, |
| DNAjc10 | ER-associated protein degradation [70] | F47B7.2, Y52E8A.3) |
|
| ||
| ERp29 | Specialist ‘‘escort” chaperone [71] Thyroglobulin processing [72] |
None |
|
| ||
| ERp46 | Some P4HB functional redundancy Protective role against hypoxia [70] |
(W01B11.6, Y55F3AR.2) |
|
| ||
| ERp44 | Possible role in late-stage oligomerization reactions Possible role in late-stage, thiol-dependent, protein quality-control system or trafficking [70] |
C06A6.5, C30H7.2 |
|
| ||
| P4HB | Thiol-disulfide exchange catalysis Role in protein folding Beta subunit of P4H complex [70] |
PDI-2, PDI-1 |
|
| ||
| PDIA2 | Expressed in pancreas and brain [73, 74] Thiol-disulfide exchange catalysis similar to P4HB Specific function still unclear |
None |
|
| ||
| PDIA3 | Involved in MHC class I folding as part of MHC I peptide-loading complex [75] Oxidative folding of glycoproteins |
PDI-3 |
|
| ||
| PDIA4 | Thiol-disulfide exchange catalysis similar to P4HB Some PDIA3 redundancy Can form part of a complex with P4HB, PDIA6, ERdj3, BiP, CypB, HSP40, GRP94, GRP170, UDP glucosyltransferase, and SDF2-L1 [76] |
C14B9.2 |
|
| ||
| PDIA5 | Unknown | (F35G2.1, T10H10.2) |
|
| ||
| PDIA6 | Likely catalyze thiol-disulfide exchange similar to P4HB Likely role in protein folding |
TAG-320, Y49E10.4 |
|
| ||
| PDILT | Unknown | None |
|
| ||
| TMX1 | ER transmembrane PDI Unknown function |
DPY-11 |
|
| ||
| TMX2 | ER transmembrane PDI Unknown function |
None |
|
| ||
| TMX3 | ER transmembrane PDI Protein dithiol-disulfide oxidant |
ZK973.11 |
|
| ||
| TMX4 | ER transmembrane PDI Unknown function |
None |
|
| ||
| TXNDC12 | Unknown | Y57A10A.23 |
Italic rowsare human proteins that share the same C. elegans paralogs.