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Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis. (a) IgG4+ plasma cells surround a glomerulus (IgG4 immunostaining ×400). (b) Accumulation of many IgG4+ plasma cells is seen in the interstitium (IgG4 immunostaining ×400). (c) Many CD138+ cells are seen in the interstitium (CD138 immunostaining ×400). (d) These plasma cells are IgG4 negative (IgG4 immunostaining x400).
