Table 2.
Histologic features of IgG4-related tubulointerstitial nephritis.
| IgG4 IHC | Glomerular | IF TBM | IF TBM | IF TBM | IF GL | IF GL | IF GL | IF GL | EM TBM | EM GL | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pt. no. | Age/gender | (cells per hpf) | IgG4/IgG | Lesion | IgG | C3 | C1q | IgG | IgA | C3 | C1q | ||
| 1 | 76/F | 50 | 81% | − | − | + | − | − | − | − | − | − | − |
| 2 | 70/M | 19 | 38% | − | NA | NA | NA | NA | NA | NA | NA | + | − |
| 3 | 59/M | 57 | 54% | − | − | − | − | − | − | − | − | NA | − |
| 4 | 63/M | 37 | 46% | − | − | + | + | − | − | − | − | − | − |
| 5 | 58/M | 21 | 81% | − | NA | NA | NA | − | − | − | NA | NA | − |
| 6 | 58/M | 156 | 77% | − | − | − | − | − | − | − | − | − | − |
| 7 | 75/M | 25 | 18% | − | − | − | − | NA | NA | NA | NA | + | − |
| 8 | 68/M | 17 | 40% | − | − | − | − | + | − | + | − | − | − |
| 9 | 75/M | 28 | 64% | − | + | + | − | − | − | − | − | ± | − |
| 10 | 55/M | 49 | 55% | − | − | − | − | ± | − | − | − | − | − |
| 11 | 69/M | 30 | 51% | − | − | − | − | + | − | − | 2+ | + | − |
| 12 | 80/M | 10 | 90% | MPGN | NA | NA | NA | 2+ | − | 2+ | + | NA | + |
| 13 | 68/M | 28 | 38% | IgA GN | − | + | − | − | 2+ | ± | ± | NA | NA |
| 14 | 79/M | 42 | 41% | EC | − | + | + | − | − | − | − | + | − |
| 15 | 69/M | 73 | 57% | EC | − | − | − | − | − | + | − | − | − |
| 16 | 72/M | 51 | 58% | HSPN | NA | NA | NA | 2+ | + | ± | − | NA | + |
| 17 | 75/F | 62 | 40% | HSPN | − | − | − | − | + | 2+ | − | − | + |
| 18 | 83/M | 25 | 43% | MGN | + | + | − | + | − | + | − | + | + |
| 19 | 60/M | 68 | 42% | MGN | − | − | − | 3+ | − | − | − | − | + |
| 20 | 78/M | 28 | 45% | MGN | − | + | − | − | − | − | − | − | + |
Abbreviations: EC: endocapillary hypercellularity; EM: electron microscopy; GL: glomeruli; hpf: high-power field; HSPN: Henoch-Schönlein purpura nephritis; IF: immunofluorescence; IgA GN: IgA nephropathy; IHC: immunohistochemistry; MGN: membranous glomerulonephritis; MPGN: membranoproliferative glomerulonephritis; NA: not available; Pt.: patient; TBM: tubular basement membranes.