Table 2.
Physicochemical parameters of microspheres.
| Formulation | Yield (%) (X ± SD) |
Actual drug content (mg) (X ± SD) |
Theoretical drug content (mg) | Drug entrapment efficiency (%) (X ± SD) |
Particle size (μm) (X ± SD) |
Moisture loss (%) |
|---|---|---|---|---|---|---|
| F1 | 85.2 ± .098 | 17.98 ± .116 | 66.66 | 26.97 ± .167 | 34.56 ± .213 | 1.07 |
| F2 | 84.00 ± .078 | 33.67 ± .014 | 50.02 | 67.34 ± .178 | 38.43 ± .265 | 1.08 |
| F3 | 81.76 ± .105 | 22.43 ± .018 | 40.21 | 55.78 ± .161 | 58.59 ± 178 | 2.25 |
| F4 | 84.8 ± .142 | 17.79 ± .011 | 33.33 | 53.37 ± .132 | 49.67 ± .189 | 1.13 |
| F5 | 78.8 ± .112 | 13.81 ± .078 | 28.57 | 48.33 ± .096 | 83.66 ± .208 | 1.22 |
| F6 | 84.8 ± .069 | 18.27 ± .063 | 28.21 | 64.76 ± .189 | 56.64 ± .228 | 1.49 |
| F7 | 88.08 ± .117 | 15.37 ± .035 | 25.22 | 60.94 ± .154 | 69.22 ± .256 | 1.43 |
| F8 | 86.68 ± .098 | 15.69 ± .021 | 26.07 | 60.18 ± .089 | 71.34 ± .159 | 1.55 |
| F9 | 84.00 ± .078 | 39.67 ± .014 | 50.02 | 67.34 ± .178 | 34.56 ± .213 | 1.07 |
| F10 | 86.90 ± .035 | 20.80 ± .032 | 50.00 | 41.60 ± .153 | 39.04 ± .194 | 0.89 |
| F11 | 76.10 ± .161 | 14.91 ± .063 | 51.09 | 29.82 ± .119 | 42.31 ± .231 | 1.12 |
| F12 | 80.50 ± .073 | 16.34 ± .124 | 50.00 | 32.68 ± .096 | 48.21 ± .176 | 1.06 |
Value represent mean ± SD (n = 3).