Table 1.
Overview of the six informatics platform-based comparative effectiveness research projects analyzed in this manuscript.
| CER Project Name | Project PI/Representative | Project-specific Funding24 | Geographic diversity | Project Website | Areas of study (# patients involved) | Number of Participating Institutions | Stage of the infrastructure and project |
|---|---|---|---|---|---|---|---|
| SPAN | Daley/ Brown | $8,272,272 | USA-based Hawaii - Georgia | popmednet.org (software platform); Hmoresearch network.org has information on the VDW | Attention-deficit hyperactivity disorder (~240,000 adolescents); obesity (~2.4million) | 11 US-based health systems |
Infrastructure: VDW in production 10 yrs, SPAN is adding new variables; developing query enhancements to the PopMedNet platform Project: Developing research protocols, initial data assessments |
| WICER | Wilcox/Wilcox | $8,855,607 | Limited to Washington Heights / Inwood community (New York City, NY) | Wicer.org | Population in research data warehouse (~200,000); population cohort analysis using community surveys (12,000); care management, new diagnostic algorithms, 3 clinical trials of (600 patients total) | 4 local organizations |
Infrastructure:Under development; Project: In planning stages |
| CER-HUB | Hazlehurst/Hazlehurst | $8,735,759 | USA-based Hawaii - Georgia | cerhub.org | Asthma (200,000); smoking cessation (500,000) | 6 large health systems – 3 HMOs, 1 VA, 1 consortium of FQHCs, 1 large regional physician/hos pital network |
Infrastructure:Under development; Project: Two studies underway |
| RPDR | Murphy/ Murphy | ~$18M over past 12 years | Limited to Boston, MA area | rc.partners.org/rpdr, I2b2.org | Supports about 400 studies/year; 4 studies have been completed,,25,26,30,31 | 7 local hospitals |
Infrastructure:System in operation since 1999 Project: Hundreds of studies underway |
| INPC COMET-AD | Dexter and Boustani/Rosenman | $8,422,410 | Indianapolis, IN metropolitan area | www.regenstrief.org/medinformatics/inpc | Drug treatment of Alzheimer's disease (300) | 5 major hospital systems in Indianapolis area |
Infrastructure: HIE used routinely for patient care and research Project: Beginning patient enrollment |
| SCOAP-CERTN | Flum/Tarczy-Hornoch | $11,690,974 | Washington state | www.scoap.org | Primary: peripheral artery disease; Secondary: under development | 10 institutions planned (3 agreed) |
Infrastructure: WA statewide QA/QI registry in use at 50+ sites for 4 + years Project: Recruiting 7 additional sites (3 agreed) |
Abbreviations: Health Maintenance Organization (HMO); Virtual Data Warehouse (VDW); Quality Assurance/Quality Improvement (QA/QI); Federally-Qualified Health Care facilities (FQHCs)