. 2012 Jun 29;27(9):2690–2697. doi: 10.1093/humrep/des216

Table II.

IVF cycle outcomes by serum estradiol response to hCG administration

	Group A (>10% rise), n = 1065	Group B (±10% plateau), n = 525	Group C (>10% fall), n = 122	P-value
Hormone response to hCG
Day of hCG E2 (pg/ml)	3017 ± 1331	3010 ± 1380	3194 ± 1430	0.56
Post-hCG E2 (pg/ml)	4051 ± 1898	3059 ± 1413	2639 ± 1157	0.0001^{a,†,b,†,c}
Day of hCG LH (mIU/ml)	1.8 ± 1.3	1.8 ± 1.3	1.5 ± 1.1	0.08
Post-hCG LH (mIU/ml)	1.4 ± 3.2	1.4 ± 1.1	1.2 ± 0.9	0.03^b
Post-hCG E2 absolute difference (pg/ml)	1034 ± 882	49 ± 178	−555 ± 446	0.0001^{a,†,b,†,c,†}
Post-hCG E2 percent difference (%)	35.1 ± 28.7	1.6 ± 5.4	−17.0 ± 6.8	0.0001^{a,†,b,†,c,†}
Number of oocytes retrieved	12.5 ± 6.8	11.0 ± 6.2	11.8 ± 6.8	0.0001^a,†
Micromanipulation
ICSI (%)	22.3	18.9	23.0	0.26
Assisted hatching (%)	30.6	40.8	32.0	<0.0001^a,†
IVF cycle outcomes
Cycles with embryos cryopreserved (%)	29.5	22.1	25.4	0.007^a
Number of embryos cryopreserved	1.8 ± 3.5	1.5 ± 3.2	1.5 ± 3.0	0.005^a
Number of embryos transferred	2.7 ± 1.0	2.8 ± 1.1	2.7 ± 1.1	0.13
Cycles without embryo transfer (n, %)	97 (9.1)	55 (10.5)	14 (11.5)	0.54
Clinical outcomes per cycle
Number of fetal heart tones (FHTs)	1.2 ± 0.7	1.3 ± 0.7	1.2 ± 0.8	0.28
Implantation(%)	20.7	16.2	14.1	0.002^a,†,b
Clinical intrauterine pregnancy (%)	38.4	28.0	23.3	<0.001^a,†,b,†
Spontaneous abortion (%)	19.7	18.7	31.8	0.55
Live birth (%)	27.6	19.3	12.5	<0.001^a,†,b,†
Multiple gestations per delivery (%)	31.2	36.0	35.8	0.57

Note: values are the mean ± SD unless otherwise noted.

^aGroup A significantly different from Group B, P < 0.05.

^bGroup A significantly different from Group C, P < 0.05.

^cGroup B significantly different from Group C, P < 0.05.

^†P value ≤ 0.001.