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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Nano Lett. 2012 Jun 20;12(7):3587–3591. doi: 10.1021/nl301253v

Figure 3. Nanoparticle size variations to controlled microvortex patterns.

Figure 3

(a) Effect of flow rate ratios (1:5, 1:10, and 1:20) of [PLGA stream] to [outer lipid streams] on nanoparticle size with respect to Reynolds number (30, 75, and 150) and PLGA-to-lipid ratios (10, 25, and 50). (b) Effect of PLGA-to-lipid ratios (10, 25, and 50) on nanoparticle size with respect to Reynolds number (30, 75, and 150) and flow rate ratios (1:5, 1:10, and 1:20). Error bars are standard deviations of different nanoparticle batches (n=5). (c) Controllable microvortices in the xy and yz planes. In a flow rate ratio of 1:5, microvortex patterns were not well developed due to relatively higher portion of the central stream in the channel while the vortices were well developed in flow rate ratios of 1:10 and 1:20. Increasing the Reynolds number resulted in clearer microvortex formation while vortex patterns were undeveloped at Re=3 (Figure S5).