Table 1.
TC Classa | Class Description | No. of Transport Proteinsb | TC Subclass | Subclass Description | No. of Transport Proteinsb |
---|---|---|---|---|---|
1. | Channels | 45 (29) | 1.A | α-type channels | 15 (12) |
1.B | β-barrel porins | 29 (16) | |||
1.C | Pore-forming toxins (proteins and peptides) | – | |||
1.D | Nonribosomally synthesized channels | – | |||
1.E | Holins | 1 (1) | |||
2. | Secondary carriers | 100 (70) | 2.A | Porters (uniporters, symporters, antiporters) | 73 (64) |
2.B | Nonribosomally synthesized porters | – | |||
2.C | Ion-gradient-driven energizers | 27 (6) | |||
3. | Primary active transporters | 227 (55) | 3.A | P-P-bond-hydrolysis-driven transporters | 202 (51) |
3.B | Decarboxylation-driven transporters | 4 (-) | |||
3.C | Methyltransfer-driven transporters | – | |||
3.D | Oxidoreduction-driven transporters | 21 (4) | |||
3.E | Light absorption-driven transporters | – | |||
4. | Group translocators | 0 | 4.A | Phosphotransfer-driven group translocators | - |
4.B | Nicotinamide ribonucleoside (NR) uptake permeases | - | |||
5. | Transmembrane electron carriers | 4 (2) | 5.A | Transmembrane 2-electron transfer carriers | 4 (2) |
5.B | Transmembrane 1-electron transfer carriers | – | |||
8. | Auxiliary transport proteins | 7 (-) | 8.A | Auxiliary transport proteins | 7 (-) |
9. | Poorly defined system | 23 (16) | 9.A | Recognized transporters of unknown biochemical mechanism | 4 (3) |
9.B | Putative uncharacterized transport proteins | 19 (13) | |||
9.C | Functionally characterized transporters lacking identified sequences | – | |||
Total | 406 (172) | 406 (172) |
Transporter classes 6 & 7 have not been assigned in the TC system yet and therefore are absent from this table.
Numbers in parentheses represent the number of transport systems.