Figure 4.

(A) Effect of different concentrations on HSYA uptake by Caco-2 monolayers after incubation with HSYA solutions for 2 hours. (B) Cumulative transport of HSYA across Caco-2 cell monolayers (surface area of monolayer = 1.12 cm2). (C) Effect of SDEDDS on Caco-2 cellular uptake. (D) Effect of SDEDDS on Caco-2 cellular transport (surface area of monolayer = 1.12 cm2).

Note: *P < 0.05, compared with control.

Abbreviations: HSYA, Hydroxysafflor yellow A; SDEDDS, self-double-emulsifying drug delivery system