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(A) Effect of p-gp inhibitors (cyclosporin A and tetramethylpyrazine) on cellular transport of HSYA solution. (B) Endocytosis inhibitor studies on Caco-2 cells of HSYA-SDEDDS with three kinds of endocytosis inhibitors and NaN3 to inhibit mitochondrion.
Note: *P < 0.05, compared with control.
Abbreviations: HSYA, Hydroxysafflor yellow A; p-gp, p-glycoprotein; SDEDDS, self-double-emulsifying drug delivery system.
