Figure 5.

(A) Confocal laser scanning microscopy of PC3M cells (prostate stem cell antigen-positive) and HT29 cells (prostate stem cell antigen-negative) after 2 hours of incubation with void nanoparticles (control), PLGA-SPIO/coumarin, and scAb-PLGA-SPIO/coumarin, respectively. (B) Mean fluorescence intensity of PC3M and HT29 cells in Figure 5A. (C) In vitro T2-weighted images (cross section and sagittal section) of untreated PC3M cells, PC3M cells incubated with scAb-PLGA-SPIO/docetaxel or PLGA-SPIO/docetaxel, and HT29 cells incubated with scAb-PLGA-SPIO/docetaxel. (D) T₂ values of PC3M and HT29 cells described in Figure 5C.

Notes: The results are shown as the mean ± standard error of the mean (n = 3). ^*P < 0.05.

Abbreviations: Dtxl, docetaxel; PLGA, poly(D,L-lactic-co-glycolic acid); SPIO, superparamagnetic iron oxide; NPs, nanoparticles.