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. 2012 Aug 9;8(8):e1002834. doi: 10.1371/journal.pgen.1002834

Figure 1. DR–essential genes are molecularly conserved and form a tight interaction network.

Figure 1

A, The proportion of genes (shown as percentages) with orthologs from multiple species in the specified organisms is in all cases higher (by 10–30%) for DR-essential genes than expected by chance. B, The average degree (number of interactions) for DR-essential genes and DR-essential gene orthologs (the ortholog-complemented set) is higher than the interactome-wide average which serves as control. C, The average percentage of specificity in interconnectivity (100× specific interactions with seed genes/all interactions) of DR-essential genes to each other is higher than for other genes in interactomes, and complementation with orthologs of DR-essential genes from other species further increases the specificity of interconnectivity. ns, P>0.05; *, P<0.05; **, P<0.01; ***, P<0.001.