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. 2012 Aug 9;8(8):e1002855. doi: 10.1371/journal.pgen.1002855

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© 2012 Fragoso et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and B) Effects of germline deletion of mir-181ab1 on (A) T lymphocyte and (B) B lymphocyte development (*, p<0.05, Mann-Whitney rank sum tests). (C) Effects of germline deletion of mir-181cd on CD8 thymocyte development. (D) Effects of mir-181a-1 ectopic expression on DP thymocyte development determined by the OP9-DL1 assay. (E) Effects of Cre-mediated deletion of mir-181ab1 on DP thymocyte development determined using the OP9-DL1 assay. (F) Effects of germline mir-181ab1 deletion and mir-181cd deletion on DP thymocyte development in the OP9-DL1 assay. (G and H) Effects of induced deletion of the mir-181ab1 alleles on thymocyte development in vivo. CreER:mir-181ab1^+/+ and CreER:mir-181ab1^f/f mice were injected with tamoxifen four times at two-day intervals to induce the deletion of mir-181ab1 alleles and analyzed at day 5 after the last tamoxifen injection to determine (G) thymic cellularity and (H) CD4/CD8 profiles. Representative results of two independent analyses are summarized or presented in (G) and (H).