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. 2012 Aug 9;8(8):e1002855. doi: 10.1371/journal.pgen.1002855

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© 2012 Fragoso et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and B) Copy numbers of mature miR-181a, miR-181b, miR181c and miR-181d in ICN1-infected DP cells from (A) ICN1:181ab1^+/+ and (B) ICN1:181ab1^−/− recipient mice at 2, 4 and 6 weeks post-transplantation determined by standard curve-based miRNA qPCR analyses. (C and D) Kaplan-Meier survival curves indicate the percentage of mice (20 mice/group) surviving at different time points after reconstituting with (C) ICN1-infected mir-181ab1/ab2^−/− (p<0.001) or (D) ICN1-infected mir-181ab1/cd^−/− BM cells (p>0.05). (E and F) Effects of loss of mir-181 family genes on the percentage of total ICN1-infected cells (all GFP⁺ cells) in peripheral blood at different time points after reconstitution (**, p<0.01).