Table 4.
Comparisons of ROH Frequencies between OMIM and Non-OMIM Genes
| Variable 1 | Variable 2 | ROH Class | D | p Value |
|---|---|---|---|---|
| Autosomal-dominant genes (n = 515) | non-OMIM genes (n = 12,491) | A | −0.051 | 0.149 |
| B | 0.048 | 0.207 | ||
| C | −0.063 | 0.039 | ||
| Autosomal-recessive genes (n = 699) | non-OMIM genes (n = 12,491) | A | −0.045 | 0.129 |
| B | −0.047 | 0.106 | ||
| C | −0.048 | 0.089 |
p values are from two-sided Kolmogorov-Smirnov tests comparing runs-of-homozygosity (ROH) frequencies between two groups. Negative values of D indicate that group 1 (left) has higher frequencies than group 2 (right). Significant p values (<0.05) are highlighted in bold.