Table 1.
Clinical characteristics of study subjects
| AN (n=7) | AN-R (n=7) | HC (n=15) | |
|---|---|---|---|
| Age (years) | 33.1 ± 2.8 | 27.6 ± 2.2 | 27.8 ± 1.2 |
| BMI (kg/m2) | 18.2 ± 0.6*⊥ | 20.8 ± 0.6 | 21.9 ± 0.4 |
| % IBW | 80.6 ± 2.2*⊥ | 94 ± 3.2 | 99.6 ± 1.3 |
| Months of amenorrhea | 80.9 ± 24.8 | ------------ | ------------ |
| Months since recovery | ------------ | 44.1 ± 17.3 | ------------ |
| PA Spine BMD (g/cm2) | 0.83 ± 0.05^⊥ | 0.96 ± 0.02 | 1.02 ± 0.02 |
| Lat Spine BMD (g/cm2) | 0.62 ± 0.03*# | 0.79 ± 0.05 | 0.79 ± 0.02 |
| Total Hip BMD (g/cm2) | 0.74 ± 0.03*⊥ | 0.94 ± 0.03 | 0.95 ± 0.03 |
| Total Body BMD (g/cm2) | 0.97 ± 0.03*# | 1.08 ± 0.01 | 1.13 ± 0.03 |
| Fat Mass by DXA (g) | 10.7 ± 1.3# | 13.8 ± 1.3 | 17 ± 1.1 |
| Lean Mass by DXA (g) | 40.6 ± 1.5 | 40 ± 1.4 | 43.5 ± 1.2 |
| % Body Fat by DXA | 19.8 ± 1.9∞ | 24.6 ± 2.1 | 26.9 ± 1.3 |
| SAT of Abdomen (cm2) | 86.1 ± 14.7∞ | 98 ± 19.8 | 157.8 ± 17.3 |
| VAT of Abdomen (cm2) | 12.6 ± 1.4± | 14.2 ± 3.4 | 34.1 ± 6.4 |
| TAT of Abdomen (cm2) | 98.7 ± 15.7∞ | 112.1 ± 21.7 | 191.9 ± 21.8 |
| SAT of Thigh (cm2) | 50.6 ± 5.8∞ | 76.6 ± 8.5 | 83.6 ± 6.3 |
| Total cross-sectional area of mid-diaphysis of femur (cm2) | 5.43 ± 0.32 | 5.34 ± 0.21 | 5.35 ± 0.15 |
| Cortical area of mid-diaphysis of femur (cm2) | 3.53 ± 0.20 | 4.02 ± 0.10 | 3.88 ± 0.13 |
| Marrow area of mid-diaphysis of femur (cm2) | 1.90 ± 0.25 | 1.32 ± 0.19 | 1.47 ± 0.09 |
| Leptin (ng/mL) | 3.7 ± 1.4 | 5.6 ± 1.6 | 7.8 ± 1.5 |
AN: anorexia nervosa; AN-R: women recovered from anorexia nervosa; HC: healthy controls;
*
p ≤ 0.03 as compared to AN-R;
^
p < 0.04 as compared to AN-R;
⊥
p ≤ 0.0005 as compared to HC;
#
p ≤ 0.005 as compared to HC;
∞
p < 0.02 as compared to HC;
±
p < 0.08 as compared to HC