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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Horm Behav. 2012 Apr 25;62(3):254–262. doi: 10.1016/j.yhbeh.2012.04.011

Fig. 1. Hematopoietic progenitors of DC are differentially regulated by ERα signaling in Flt3L and GM-CSF mediated developmental pathways.

Fig. 1

Long-term repopulating hematopoietic progenitors (LSK-flt3−) progress through LSK-flt3+ progenitors which branch into myeloid (MP) and lymphoid (LP) progenitors. For DC development, MP yield the macrophage-DC progenitor (MDP) and common DC progenitor (CDP). In Flt3L-mediated DC development during homeostasis, the CDP yields plasmacytoid DC (pDC) and pre-cDC, the immediate precursors of conventional DC (cDC) and some tissue DC (tDC). Estradiol (E)/ERα signaling decreases the number of DC that develop along this pathway (blue dashed circle). In the GM-CSF-driven pathway, MP give rise to MDP and monocytes that differentiate to populations of inflammatory DC and some tDC. Estradiol/ERα signaling promotes this developmental pathway (red solid circle). LP also yield some DC populations in vivo (not shown). This figure was adapted from (Schmid et al., 2010).