Table 4.
Association of Prostate Cancer with HOXB13 G84E in strata of age of diagnosis, and disease aggressiveness.
| Affected in Pedigreea | Stratum | Carrier Rate (%) | OR (95% CI) | P |
|---|---|---|---|---|
| ≥ 2 | ≤ 60b | 8 of 435 (0.018) | 9.9 (1.4 – 68.6) | 0.020 |
| ≥ 2 | ≥ 61 | 8 of 423 (0.019) | 7.7 (1.6 – 37.0) | 0.011 |
| ≥ 2 | Gleason ≤ 6 | 7 of 433 (0.016) | 6.4 (1.3 – 32.1) | 0.023 |
| ≥ 2 | Gleason ≥ 7 | 9 of 400 (0.023) | 9.9 (2.1 – 46.0) | 3.5 × 10−3 |
| ≥ 2 | ≥ pT3, N1, or M1 | 4 of 175 (0.023) | 9.7 (1.8 – 53.5) | 9.2 × 10−3 |
| ≥ 3 | ≤ 60 | 5 of 177 (0.028) | 13.9 (1.8 – 105.5) | 0.011 |
| ≥ 3 | ≥ 61 | 4 of 152 (0.026) | 10.2 (1.8 – 57.8) | 8.9 × 10−3 |
| ≥ 3 | Gleason ≤ 6 | 5 of 180 (0.028) | 11.3 (2.0 – 62.4) | 5.5 × 10−3 |
| ≥ 3 | Gleason ≥ 7 | 4 of 135 (0.030) | 13.1 (2.4 – 72.4) | 3.2 × 10−3 |
| ≥ 3 | ≥ pT3, N1, or M1 | 3 of 57 (0.053) | 23.3 (3.8 – 143.0) | 6.8 × 10−4 |
a
First and second degree relatives (0, controls; 1, case probands with no others in pedigree affected; 2, case probands with one additional in pedigree affected, etc).
b
Proband age of diagnosis.