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. Author manuscript; available in PMC: 2013 May 23.
Published in final edited form as: J Am Chem Soc. 2012 Apr 10;134(20):8543–8550. doi: 10.1021/ja3004655

Figure 4.

Figure 4

Correlation of the pressure sensitivity of methyl bearing side chain motion in ubiquitin with their amplitude of motion at 1 bar. Only methyl groups showing a simple linear pressure dependence are shown. Methyls having a non-linear pressure dependence and/or residing in a region with significant pressure induced structural changes were excluded from the analysis (see text). Six outliers (red) were identified using the interquartile range method (see Methods). Linear regression of the remaining points gave a slope of -0.07 ± 0.01 kbar-1 and R of 0.9. This pressure response reflects a variable local compressibility of the protein.