Fig. 7.

The effect of saracatinib on the ability of KHT sarcoma cells to induce angiogenesis was determined by either pretreating the tumor cells for 24 h with saracatinib (0–5 μM) prior to injection (a) or treating the mice with daily 10 mg/kg doses of saracatinib post tumor cell inoculation (b). Bars and hatched areas = 90% and 75% confidence intervals, respectively; stars = statistical significance of p < 0.05 (Wilcoxon’s rank-sum test) compared with controls.