Table 1.
Agonist potencies (pEC50 values) for cAMP production at rCT(a), rAMY1(a) and rAMY3(a) receptors
| Agonist | rCT(a) receptor | rAMY1(a) receptor | rAMY3(a) receptor |
|---|---|---|---|
| rAmy | 8.11 ± 0.12 (15) | 9.74 ± 0.10 (23)*** | 9.97 ± 0.11 (18)*** |
| rCT | 9.28 ± 0.20 (11) | 8.90 ± 0.37 (6) | 8.30 ± 0.40 (4)* |
| rαCGRP | 7.87 ± 0.28 (7) | 9.66 ± 0.13 (13)*** | 9.68 ± 0.08 (6)*** |
| rβCGRP | 7.54 ± 0.25 (7) | 8.87 ± 0.27 (9)* | 8.95 ± 0.20 (6) |
| (Cys(ACM)2,7)hαCGRP | <6 (4) | <6 (4) | <6 (4) |
| (Cys(Et)2,7)hαCGRP | <6 (4) | <6 (4) | 7.70 ± 0.39 (4)a |
| rAM | 6.82 ± 0.39 (6) | 7.12 ± 0.26 (4) | 8.04 ± 0.17 (5)*,+ |
| rAM2 | 6.97 ± 0.30 (6) | 7.92 ± 0.27 (4) | 8.68 ± 0.09 (5)*** |
Data are mean ± SEM. Values in parentheses represent the number of individual experiments analysed.
a
Weak partial agonist. Comparisons between receptors were performed by one-way anova followed by Tukey's test (vs. rCT(a),
*
P < 0.05;
**
P < 0.01;
***
P < 0.001. vs. rAMY1(a),
+
P < 0.05). Comparisons of agonists within each column can be found in Figure 3 and Tables S1–S3.