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CAT-354 is a potent and selective neutralizer of IL-13. (A) Baculovirus-derived human, human R130Q and cynomolgus IL-13-induced TF-1 cell proliferation (n= 6). (B) Recombinant mouse IL-13-induced HUVEC VCAM-1 upregulation (n= 3). (C) Endogenous IL-13-driven HDLM-2 cell proliferation (n= 2). (D) Recombinant human IL-13, IL-4 and IL-1β-induced HUVEC VCAM-1 upregulation (n= 5, 3, 6 respectively). Data are shown as mean average points ± SEM from n independent experiments.
