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. 2012 May;166(1):177–193. doi: 10.1111/j.1476-5381.2011.01659.x

Figure 4.

Figure 4

Effects of CAT-354 on the allergic phenotype in humanized BALB/c mice. (A) Model schematic. Daily mAb dosing. (B) Airway hyperresponsiveness (n= 4–8). 72h mAb dosing. (C) BAL eosinophilia with inset % eosinophils (n= 20–25); (D) Airway hyperresponsiveness (n= 14–18 except dex n= 8); (E) Forced expiratory volume (n= 6–8). Data are shown as mean average ± SEM from 1 (B) or 2 (C–E) blocked experiments. *P < 0.05; **P < 0.01; ***P < 0.001 versus s/c group using one-way (two-way for AHR) anova followed by Dunnett's (Bonferroni's for AHR) multiple comparisons test using s/c as the control group.