Table 1.

Bioreduction of different substrates with SYE-4 proteins

Entry	Substrate		Time	Conv. (%)a	ee (%)	Abs. config.	Product
Ketones
1	1a (R=2-Me)		6 h	92	52	nd	2a
2	1b (R=3-Me)		6 h	nc	na	na	2b
3	1c		6 h	nc	na	na	2c
4	1d (n=1)		6 h	4	rac	na	2d
5	1e (n=2)		6 h	92	51	nd	2e
6	1f (n=1)		6 h	30	na	na	2f
7	1g (n=2)		6 h	71	na	na	2g
8	1h (+)-Carvone		1 h	100	97b	2R,5R	2h
9	1i (−)-Carvone		1 h	100	95c	2R,5S	2i
Diesters
10	1j (R=Me)		6 h	99	98	R	2j
11	1k (R=Et)		6 h	99	99	R	2k
12	1l (R=Me)		6 h	19	90	R	2j
13	1m (R=Et)		6 h	nc	na	na	2k
Imides
14	1n (R1=Me; R2=Me)		1 h	99	99	R	2n
15	1o (R1=Me; R2=Et)		3 h	99	99	R	2o
16	1p (R1=Me; R2=Propyl)		3 h	>99	99	R	2p
17	1q (R1=Me; R2=Butyl)		3 h	99	99	R	2q
18	1r (R1=Me; R2=Allyl)		3 h	99	99	R	2r
19	1s (R1=Me; R2=Bn)		3 h	99	99	R	2s
20	1t (R1=H; R2=Allyl)		1 h	99	na	na	2t
21	1u (R1=H; R2=Bn)		1 h	98	na	na	2u

nd=not determined; na=not applicable.

^aConversion based on GC.

^bDiastereomeric excess (trans).

^cDiastereomeric excess (cis).