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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jun 23;22(16):5297–5302. doi: 10.1016/j.bmcl.2012.06.036

Figure 2.

Figure 2

Compound 22 (turquois sticks) forms five hydrogen-bonding interactions with Src; A. Two hydrogen bonds are made with the hinge region: between the thiazole N and backbone NH of M341 and between the cyclopropyl amide NH and the backbone carbonyl of M341. B. Hydrogen bonding interactions exist between the benzamide carbonyl of 22 and the backbone NH of D404 of the DFG-motif, between the benzamide NH and side-chain carboxylate of E310 from the C-helix, and from the presumably protonated distal piperazine nitrogen and the backbone carbonyls of V383 and H384.