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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jun 23;22(16):5297–5302. doi: 10.1016/j.bmcl.2012.06.036

Table 3.

Cellular antiproliferation activity of analogs 24–33.

Compds Structure Cellular antiproliferative activity (EC50, μM)
Bcr-Abl (wt) Bcr-Abl (T315I) Ba/F3
24 graphic file with name nihms396366t8.jpg 2.31 2.30 2.30
25 graphic file with name nihms396366t9.jpg >10 >10 >10
26 graphic file with name nihms396366t10.jpg 0.38 0.19 1.99
27 graphic file with name nihms396366t11.jpg 0.001 0.06 1.23
28 graphic file with name nihms396366t12.jpg 0.03 0.56 4.67
29 graphic file with name nihms396366t13.jpg 0.02 0.30 >10
30 graphic file with name nihms396366t14.jpg 0.02 0.59 >10
31 graphic file with name nihms396366t15.jpg 0.2 0.78 >10
32 graphic file with name nihms396366t16.jpg 0.018 0.013 0.69
33 graphic file with name nihms396366t17.jpg 1.24 0.55 >10