Figure 4. Adapted Ingenuity figure for mitochondrial dysfunction demonstrating the differences in gene transcription in UOK262 and the normal renal cell line HK-2.
The mitochondrial dysfunction pathway was identified by the Ingenuity® Pathways Analysis software (https://analysisingenuity.com) as the most significantly altered biological function in UOK262 compared to the normal renal cell line HK-2. Genes transcripts up-regulated in UOK268 are highlighted in green and down-regulated are highlighted in red. This figure was adapted by removing the aspects of the pathway containing no significantly dysregulated transcripts.
