Table 3.

Significantly dysregulated transcripts involved in mitochondrial dysfunction identified by Ingenuity® Pathways Analysis software or known function.

	Gene	Location	Entrez Gene Name	Selection
↑	GPX7	Cytoplasm	glutathione peroxidase 7	Ingenuity Mitochondrial Dysfunction Pathway
↓	CYB5R3	Outer Mitochondrial Membrane	cytochrome b5 reductase 3	Ingenuity Mitochondrial Dysfunction Pathway
↓	CPT1B	Outer Mitochondrial Membrane	carnitine palmitoyltransferase 1B (muscle)	Ingenuity Mitochondrial Dysfunction Pathway
↑	CPT1A	Outer Mitochondrial Membrane	carnitine palmitoyltransferase 1A (liver)	Ingenuity Mitochondrial Dysfunction Pathway
↑	CPT1C	Outer Mitochondrial Membrane	carnitine palmitoyltransferase 1C	Ingenuity Mitochondrial Dysfunction Pathway
↑	APP	Outer Mitochondrial Membrane	amyloid beta (A4) precursor protein	Ingenuity Mitochondrial Dysfunction Pathway
↑	MAOA	Outer Mitochondrial Membrane	monoamine oxidase A	Ingenuity Mitochondrial Dysfunction Pathway
↓	OGDH	Inner Mitochondrial Membrane	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Ingenuity Mitochondrial Dysfunction Pathway
↑	GPX4	Mitochondrial Matrix	glutathione peroxidase 4 (phospholipid hydroperoxidase)	Ingenuity Mitochondrial Dysfunction Pathway
↑	PRDX5	Mitochondrial Matrix	peroxiredoxin 5	Ingenuity Mitochondrial Dysfunction Pathway
↓	NDUFS1	Complex I	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	Ingenuity Mitochondrial Dysfunction Pathway
↓	NDUFV1	Complex I	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	Ingenuity Mitochondrial Dysfunction Pathway
↓	NDUFA9	Complex I	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	Ingenuity Mitochondrial Dysfunction Pathway
↑	MTND4	Complex I	NADH dehydrogenase, subunit 4 (complex I)	Ingenuity Mitochondrial Dysfunction Pathway
↑	MTND5	Complex I	NADH dehydrogenase, subunit 5 (complex I)	Ingenuity Mitochondrial Dysfunction Pathway
↑	NDUFB1	Complex I	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	Ingenuity Mitochondrial Dysfunction Pathway
↑	NDUFB5	Complex I	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	Ingenuity Mitochondrial Dysfunction Pathway
↑	NDUFB8	Complex I	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	Ingenuity Mitochondrial Dysfunction Pathway
↓	SDHD	Complex II	succinate dehydrogenase complex, subunit D, integral membrane protein	Ingenuity Mitochondrial Dysfunction Pathway
↓	UQCRC2	Complex III	ubiquinol-cytochrome c reductase core protein II	Ingenuity Mitochondrial Dysfunction Pathway
↑	UQCRC1	Complex III	ubiquinol-cytochrome c reductase core protein I	Ingenuity Mitochondrial Dysfunction Pathway
↑	CYB5B	Complex III	cytochrome b	Ingenuity Mitochondrial Dysfunction Pathway
↑	CYC1	Complex III	cytochrome c-1	Ingenuity Mitochondrial Dysfunction Pathway
↓	COX6A1	Complex IV	cytochrome c oxidase subunit VIa polypeptide 1	Ingenuity Mitochondrial Dysfunction Pathway
↓	COX7A2	Complex IV	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	Ingenuity Mitochondrial Dysfunction Pathway
↓	COX7C	Complex IV	cytochrome c oxidase subunit VIIc	Ingenuity Mitochondrial Dysfunction Pathway
↓	MTCO3	Complex IV	cytochrome c oxidase III	Ingenuity Mitochondrial Dysfunction Pathway
↑	COX6C	Complex IV	cytochrome c oxidase subunit VIc	Ingenuity Mitochondrial Dysfunction Pathway
↑	COX7A2L	Complex IV	cytochrome c oxidase subunit VIIa polypeptide 2 like	Ingenuity Mitochondrial Dysfunction Pathway
↓	ATP5F1	Complex V	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1	Known Function
↓	ATP5G3	Complex V	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3	Known Function
↓	ATP5S	Complex V	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)	Known Function
↑	ATP5A1	Complex V	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	Ingenuity Mitochondrial Dysfunction Pathway
↑	ATP5G2	Complex V	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2	Known Function