. Author manuscript; available in PMC: 2012 Aug 10.

Published in final edited form as: J Pharm Sci. 2010 Mar;99(3):1626–1637. doi: 10.1002/jps.21934

Table 2.

The hepatic disposition parameters of the parent MP, DMP-1, and DMP-5 and the MP regenerated from DMP-1 or DMP-5 after single 5 mg/kg (MP equivalent) intravenous doses of the parent drug or the prodrugs

Injected Drug	MP	DMP-1		DMP-5
Measured Analyte	MP	MP	DMP-1	MP	DMP-5
C_max, μg/g	1.14 ± 0.45	1.02 ± 0.41	35.6 ± 4.49^a	1.09 ± 0.69	18.1 ± 1.44^a
T_max, h	0	1.5	1.5	3	1.5
AUC_last, μg h/g	0.927 ± 0.088^b	7.63 ± 1.10^b	560 ± 42^a	9.57 ± 0.87^b	143 ± 6 ^a
AUC_0-∞, μg h/g	1.10	15.0	842	10.8	239
Liver:Plasma AUC Ratio	2.29	-^c	8.40	-^c	2.98
MRT, h	1.02	17.2	21.6	9.79	13.0
T_1/2, h	0.708	12.3	15.0	7.47	9.07

Significant difference between DMP-1 and DMP-5.

Significant differences between parent MP and MP regenerated from DMP-1 or between parent MP and MP regenerated from DMP-5.

Not estimated because of the lack of accurate estimate of plasma AUC.