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In situ detection of RAR-β2 and COX-2 mRNA expression. Paraffinembedded sections were from patients with oral premalignant lesions treated with 13-cis RA for 3 mo. Biopsy specimens were collected both before and after treatment and processed for in situ hybridization analysis of RAR-β2 and COX-2 mRNA expression by using digoxigenin-labeled probes.
